Do you have 20 or more browser tabs open at all times? Are you tired of some random site or Flash ad crashing your browser and causing you to lose your (say) Google Docs data in another tab? If so, Site Specific Browsers (SSBs) provide a great solution for your WebApp woes. Using Fluid, you can create SSBs to run each of your favorite WebApps as a separate Cocoa desktop application. Fluid gives any WebApp a home on your Mac OS X desktop complete with Dock icon, standard menu bar, logical separation from your other web browsing activity, and many, many other goodies.
Mac OS X 10.5 or later